Creating a website is a simple process. Click on the big, blue Create New Site button on the main Dashboard page to get started.
Enter in the site name, the secure internal url to be used, and a few other settings. Then select the Template Site you would like to use from YikeSite defaults, or from ones you have created yourself. Finally set up users specific to that site, and/or select members of your team that will have access to the site, and the permissions they will have.
Now you are ready to get working on your site.